Background: Chronic non-healing ulcers are a major cause of morbidity and healthcare burden due to prolonged healing, recurrent infections, and reduced quality of life. Conventional wound care often fails to achieve satisfactory healing because of persistent inflammation and impaired tissue repair. Platelet-rich plasma (PRP), an autologous concentrate of platelets rich in growth factors, has emerged as a promising adjunctive therapy by promoting angiogenesis, collagen synthesis, and tissue regeneration. However, evidence regarding its effectiveness in chronic non-healing ulcers remains variable. Therefore, this study was undertaken to evaluate the efficacy of autologous PRP in reducing the surface area of chronic non-healing ulcers and promoting wound healing.

Methods: A prospective observational study was conducted at the Department of General Surgery, K H Patil Institute of Medical Sciences, Gadag, from March 2024 to March 2026. A total of 162 patients with chronic non-healing ulcers were included. Following clinical evaluation and wound debridement, autologous PRP was prepared using the double-centrifugation technique and applied topically at regular intervals. Ulcer surface area was measured at baseline and during follow-up over six weeks. The primary outcome was reduction in ulcer surface area, while secondary outcomes included complete ulcer healing and time to healing. Statistical significance was considered at p < 0.05

Results: A significant reduction in mean ulcer surface area was observed throughout the six-week follow-up period (p < 0.001). Most patients demonstrated progressive wound contraction, with a substantial proportion achieving complete ulcer healing. Venous ulcers showed the highest healing rates, whereas trophic ulcers had the poorest response to treatment. No major adverse events related to PRP therapy were observed.