Radicular cysts are common inflammatory lesions of odontogenic origin that may cause extensive bone destruction when diagnosis and treatment are delayed. Large lesions involving multiple teeth often require multidisciplinary management to achieve favourable functional and esthetic outcomes. A 40-year-old male presented with a large anterior maxillary swelling associated with multiple non-vital teeth and a history of dental trauma. Panoramic radiography demonstrated a well-defined radiolucent lesion extending from teeth 11 to 24 with root resorption. Treatment included endodontic therapy, surgical enucleation, apicectomy, platelet-rich plasma placement, guided tissue regeneration using a collagen membrane, and definitive prosthodontic rehabilitation. Histopathological examination confirmed the diagnosis of a radicular cyst. Progressive bone healing was evident throughout the follow-up period, with complete resolution of the radiolucent defect and restoration of normal trabecular architecture observed after four years. This case highlights the successful multidisciplinary management of a large trauma-associated anterior maxillary radicular cyst, demonstrating complete radiographic healing and stable functional and esthetic outcomes over four years.