International Journal of Surgery and Surgical Research

International Journal of Surgery and Surgical Research


International Journal of Surgery and Surgical Research
International Journal of Surgery and Surgical Research
2020, Vol. 2, Issue 1
The effect of sevoflurane and desflurane on lung tissue damage after distant organ ischemia and reperfusion in diabetic rats

İlknur Aytekin Çelik, Şaban Cem Sezen, Muhammed Enes Aydın, Naciye Türk Özterlemez, Mustafa Arslan, Meral Erdal Erbatur, Mustafa Kavutçu

Objectives: Desflurane and sevoflurane are commonly used as inhaler agents in anesthesia. Although the protector effects of volatile anesthetics on the brain, heart and liver are well known, their effects on distant organ induced injuries in the lungs is not clearly understood. We examined the lungs, about the iscemia-reperfusion (I/R) distant organ damage for sevoflurane and desflurane. Methods: Diabetic animals were randomly divided into five groups, which had six animals. The groups were like this; first group was control group without diabetes. Second group was diabetic control group (DC), Third group was diabetic I/R ( D-I/R), Fourth group was diabetic I/R group with desflurane(D-I/R-D), and the fifth group was diabetic I/R group with sevoflurane (D-I/R-S) Results: Neutrophile infiltration/aggregation rate was fairly high in the DIR group when compared to other four groups DC, C, DIRS and DIRD. (p<0.0001, p<0.0001, p=0.00+95, p=0.005, respectively), Alveolar wall thickening in lung tissue was found significantly higher in the DIR group compared to the C and DC groups (p<0.0001, p<0.0001, respectively). The lung tissue injury score was found significantly higher in the DIR group compared to the C, DC, DIRD and DIRS groups (p<0.0001, p<0.0001, p=0.004, p=0.004, respectively), Conclusion: Sevoflorane and desflorane have positive effects on MDA, SOD and LTIS parameters in I/R damage on the distant organ lungs.
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How to cite this article:
İlknur Aytekin Çelik, Şaban Cem Sezen, Muhammed Enes Aydın, Naciye Türk Özterlemez, Mustafa Arslan, Meral Erdal Erbatur, Mustafa Kavutçu. The effect of sevoflurane and desflurane on lung tissue damage after distant organ ischemia and reperfusion in diabetic rats. International Journal of Surgery and Surgical Research, Volume 2, Issue 1, 2020, Pages 01-05
International Journal of Surgery and Surgical Research